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Ethanol → 6-[(6-Ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 1,4-Dimercapto-2,3-butanediol | HCID 19001 | — |
| 反応物 | 2-Amino-6-thiocyanato-1,3-benzothiazole | HCID 81600 | — |
| 反応物 | 3-Chloro-6-ethoxy[1,2,4]triazolo[4,3-b]pyridazine | HCID 67524522 | — |
| 触媒 | Monobasic potassium phosphate | HCID 516951 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-[(6-Ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine | HCID 42598895 | 80.3% |
反応手順
The 6-[(6-ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine was prepared according to the method described in Example 17a, but using 587 mg of 2-amino-1,3-benzothiazol-6-yl thiocyanate (commercial), 20 cm3 of degassed ethanol, 13 mg of potassium dihydrogen phosphate in 0.2 cm3 of water, 1.31 g of DL-dithiothreitol and 562 mg of 3-chloro-6-ethoxy[1,2,4]triazolo[4,3-b]pyridazine. 783 mg of 6-[(6-ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine are thus obtained in the form of a whitish powder, the characteristics of which are as follows:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09321777B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-542b229f19334344b5bc98c618b6372f |
| 出典メモ | uspto-grants-2016_04 |