Sodium methanesulfinate → 3-Bromo-2-chloro-5-((methylsulfonyl)methyl)pyridine

HRID 633593ノート

反応式

HRID 633593 の反応式
[CH3:1][S:2]([O-:4])=[O:3].[Na+].[Br:6][C:7]1[C:8]([Cl:15])=[N:9][CH:10]=[C:11]([CH2:13]Br)[CH:12]=1>CN(C)C=O.O>[Br:6][C:7]1[C:8]([Cl:15])=[N:9][CH:10]=[C:11]([CH2:13][S:2]([CH3:1])(=[O:4])=[O:3])[CH:12]=1

参加物

5

反応物 2

HCID 2733271Sodium methanesulfinateHCID 848198723-Bromo-5-(bromomethyl)-2-chloropyridine

生成物 1

HCID 904175713-Bromo-2-chloro-5-((methylsulfonyl)methyl)pyridine収率 84.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
65 °C

実験手順

Sodium methanesulfinate (0.748 g, 7.32 mmol) and the product from Example 143A (1.9 g, 6.66 mmol) were combined in N,N-dimethylformamide (4.44 mL) and heated at 65° C. for 1 hour. The reaction mixture was cooled and diluted with 200 mL of cold water producing a precipitate that was collected by filtration and dried to constant mass affording the title compound (1.6 g, 84%).

後処理

  1. temperatureThe reaction mixture was cooled
  2. filtrationwas collected by filtration
  3. customdried to constant mass

出典と根拠

ORDレコード
ord-29d94dafc13c4b9a8f9e4c87248892b3
出典データセット
uspto-grants-2016_04
特許番号
US09321764B2

反応ノート

読み込み中…