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Sodium Azide → 2-Phenoxy-2-oxo-6-(azidomethyl)-1,2-oxaphosphorinane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 2-Phenoxy-2-oxo-6-iodomethyl-1,2-oxaphosphorinane | HCID 19793129 | — |
| 触媒 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 溶媒 | Benzene dimethylformamide | HCID 19608675 | — |
| 生成物 | 2-Phenoxy-2-oxo-6-(azidomethyl)-1,2-oxaphosphorinane | HCID 19793120 | 96% |
反応手順
A suspension containing two equivalents of sodium azide, one equivalent of the above-prepared iodonated oxaphosphorinane and a catalytic amount of about 0.1 equivalent of tetrabutylammonium bromide in benzene/DMF (1:1) was heated to 60-80 degrees C. for 16 hours to produce 2-phenoxy-2-oxo-6-(azidomethyl)-1,2-oxaphosphorinane in 96 percent yield as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05248611 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-e5f02821feab4e68bc5f37db01f810ce |
| 出典メモ | uspto-grants-1993_09 |