Ammonium Hydroxide → 1-(2-Aminopyridin-5-yl)ethanone
反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[OH-].[NH4+:12]>>[NH2:12][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1参加物
3
反応条件
- 温度
- 130 °C
実験手順
2 g (11.57 mmol) of 1-(6-chloropyrid-3-yl)ethanone and 70 mL of ammonium hydroxide are placed in a Parr reactor. The solution is heated at 130° C. overnight. The mixture obtained is evaporated to dryness, and the residue is taken up in ethyl acetate and washed with water and with saturated NaCl solution. The organic phase is dried over sodium sulfate and evaporated to dryness to give 1.14 g of 1-(6-aminopyrid-3-yl)ethanone, the characteristics of which are as follows:
後処理
- customThe mixture obtained
- customis evaporated to dryness
- washwashed with water and with saturated NaCl solution
- dry with materialThe organic phase is dried over sodium sulfate
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-bb41f7a833024d76b26c12616ecec026
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09321790B2
反応ノート
読み込み中…