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Water → 2,4-Dimethyl-6-(3-pyridinyl)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2-Bromo-4,6-dimethylphenol | HCID 299976 | — |
| 反応物 | 3-Pyridinylboronic acid | HCID 2734378 | — |
| 触媒 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 溶媒 | Water 1,2-dimethoxyethane | HCID 18180031 | — |
| 生成物 | 2,4-Dimethyl-6-(3-pyridinyl)phenol | HCID 90002455 | 70.3% |
反応手順
2-bromo-4,6-dimethylphenol (1 g, 5 mmol) was dissolved in dimethoxyethane/water (2:1). Pyridin-3-ylboronic acid (0.62 g, 5 mmol) and Pd(dppf)Cl2 (0.20 g, 0.25 mmol), sodium carbonate (2.1 g, 25 mmol) were added thereto, followed by stirring for 1 hour under reflux. After the completion of the reaction, the reaction mixture was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, concentrated under reduced pressure, and purified by column chromatography to obtain 2,4-dimethyl-6-(pyridin-3-yl)phenol (0.7 g, 70%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447083B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-d1d0cdab6b9e420f8018c3c663768b30 |
| 出典メモ | uspto-grants-2016_09 |