Hydrochloric Acid → 4-[(4-Fluorophenoxy)methyl]piperidine hydrochloride
反応式
[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[ClH:23]>ClCCl.O1CCOCC1>[ClH:23].[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[CH:21][CH:22]=1参加物
5
実験手順
To a cooled solution of tert-butyl 4-[(4-fluorophenoxy)methyl]piperidine-1-carboxylate (538 mg, 1.74 mmol; which may be prepared as described in Step 1) in dichloromethane (11.5 mL) was added dropwise HCl 4N in dioxane (8.5 mL). The solution was warmed to room temperature and stirred for 1 h. The solvent was evaporated under reduced pressure to give the title compound (416 mg, 97%) as a white solid.
後処理
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-b39806349c864865bff1083dfae7671e
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09321769B2
反応ノート
読み込み中…