4-Fluoro-2-(3-furanyl)-6-methylphenol → 4-Fluoro-2-methyl-6-(tetrahydro-3-furanyl)phenol

HRID 63389ノート

反応式

HRID 63389 の反応式
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([OH:9])=[C:4]([C:10]2[CH:14]=[CH:13][O:12][CH:11]=2)[CH:3]=1>CO.[C].[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[CH2:14][CH2:13][O:12][CH2:11]2)[C:5]([OH:9])=[C:6]([CH3:8])[CH:7]=1

参加物

4

反応物 1

HCID 900021994-Fluoro-2-(3-furanyl)-6-methylphenol2 回

生成物 1

HCID 900024614-Fluoro-2-methyl-6-(tetrahydro-3-furanyl)phenol収率 76.5%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

4-fluoro-2-(furan-3-yl)-6-methylphenol (Compound 6-11) (471 mg, 2.45 mmol) were dissolved in methanol. Palladium carbon (64.3 mg, 5 wt %) was added thereto, followed by stirring under hydrogen balloon for 24 hours. After the completion of the reaction, the reaction mixture was filtered through Celite. The filtrate was concentrated under reduced pressure. The concentrate was purified by column chromatography (silica gel; hexane/ethyl acetate, 9/1) to obtain 4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenol (368 mg, 76%) as a white solid.

後処理

  1. customAfter the completion of the reaction
  2. filtrationthe reaction mixture was filtered through Celite
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customThe concentrate was purified by column chromatography (silica gel; hexane/ethyl acetate, 9/1)

出典と根拠

ORDレコード
ord-e773a31ef3d840e982973265efadae63
出典データセット
uspto-grants-2016_09
特許番号
US09447083B2

反応ノート

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