Hydrochloric Acid → 3-pyrrolidin-3-yloxypyridine:hydrochloride

HRID 633896ノート

反応式

HRID 633896 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][CH:8]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)[CH:2]=1.[ClH:20]>ClCCl.O1CCOCC1>[ClH:20].[NH:10]1[CH2:11][CH2:12][CH:8]([O:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH2:9]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 10801570tert-Butyl 3-(pyridin-3-yloxy)pyrrolidine-1-carboxylate

生成物 1

HCID 534092893-pyrrolidin-3-yloxypyridine:hydrochloride収率 58%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a cooled solution of tert-butyl 3-(pyridin-3-yloxy)pyrrolidine-1-carboxylate (600 mg, 2.27 mmol; which may be prepared as described in Step 1) in dichloromethane (15 mL) was added dropwise HCl 4N in dioxane (11.1 mL). The solution was warmed to room temperature and stirred for 1 h. The solvent was evaporated under reduced pressure to give the title compound (263 mg, 58%) as a yellow wax.

後処理

  1. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-d17e2412df954aba8005f0b45f0c759e
出典データセット
uspto-grants-2016_04
特許番号
US09321769B2

反応ノート

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