Hydrochloric Acid → 5-((Azetidin-3-yloxy)methyl)thiazole hydrochloride
反応式
[ClH:1].[S:2]1[C:6]([CH2:7][O:8][CH:9]2[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)=[CH:5][N:4]=[CH:3]1>C(OCC)C>[ClH:1].[NH:11]1[CH2:12][CH:9]([O:8][CH2:7][C:6]2[S:2][CH:3]=[N:4][CH:5]=2)[CH2:10]1参加物
4
実験手順
A solution of HCl in diethylether (2N, 5.5 mL) was added to a solution of tert-butyl 3-(thiazol-5-ylmethoxy)-azetidine-1-carboxylate (150 mg, 0.55 mmol) in diethylether (2 mL) at room temperature. The reaction mixture was stirred 30 minutes then concentrated to dryness. After trituration in diethyl ether (10 mL), the title compound was obtained as a yellow solid (113 mg, quantitative).
後処理
- concentrationthen concentrated to dryness
出典と根拠
- ORDレコード
- ord-18436d2da3524894b492a962acc2dd24
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09321769B2
反応ノート
読み込み中…