Bromine → 2-Amino-5-bromonicotinaldehyde hydrobromide

HRID 633975

反応式

HRID 633975 の反応式
[Br:1]Br.[NH2:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][CH:7]=[CH:6][N:5]=1>C(O)(=O)C>[BrH:1].[NH2:3][C:4]1[N:5]=[CH:6][C:7]([Br:1])=[CH:8][C:9]=1[CH:10]=[O:11]

参加物

4

反応物 2

HCID 24408BromineHCID 7376333-Pyridinecarboxaldehyde, 2-amino-

生成物 1

HCID 866061462-Amino-5-bromonicotinaldehyde hydrobromide収率 165.3%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

A solution of bromine (1.05 mL, 20.0 mmol) in acetic acid (20 mL) was added to a solution of 2-amino-3-pyridinecarboxaldehyde (2.5 g, 20 mmol) in acetic acid (50 mL) at room temperature. The reaction mixture was then stirred overnight. The resulting precipitate was filtered and washed with diethyl ether to give the title compound as a white solid (4.66 g, 80%).

後処理

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-7d7ab6aa56a64900bf92e710f3f0f273
出典データセット
uspto-grants-2016_04
特許番号
US09321769B2

関連ノート

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