4-Methoxybenzyl isothiocyanate → 2-(1H-indole-5-carbonyl)-N-(4-methoxybenzyl)hydrazinecarbothioamide

HRID 634087ノート

反応式

HRID 634087 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]([NH:12][NH2:13])=[O:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[N:14]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)=[C:15]=[S:16]>CCO>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]([NH:12][NH:13][C:15](=[S:16])[NH:14][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)=[O:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

参加物

4

反応物 2

HCID 1231974-Methoxybenzyl isothiocyanateHCID 227221541H-Indole-5-carbohydrazide

生成物 1

HCID 867250872-(1H-indole-5-carbonyl)-N-(4-methoxybenzyl)hydrazinecarbothioamide収率 51%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 1H-indole-5-carbohydrazide (0.7 g, 3.98 mmol) and 1-isothiocyanatomethyl-4-methoxy-benzene (1.0 g, 5.56 mmol) in EtOH (10 mL) was heated to reflux for 2 h. The solvent was then removed in vacuo and the residue was triturated with EtOH (5 mL) to give 2-(1H-indole-5-carbonyl)-N-(4-methoxybenzyl)-hydrazinecarbothioamide (0.7 g, 2.0 mmol, 51%) as a white solid. MS (ESI, pos. ion) m/z: 355 (M+1).

後処理

  1. temperatureto reflux for 2 h
  2. customThe solvent was then removed in vacuo
  3. customthe residue was triturated with EtOH (5 mL)

出典と根拠

ORDレコード
ord-de7087b668244f2a96d852ca1624140a
出典データセット
uspto-grants-2016_04
特許番号
US09321756B2

反応ノート

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