Hydrochloric Acid → 1,2,3,6-Tetrahydropyridine-4-boronic acid, pinacol ester hydrochloride
反応式
[CH3:1][C:2]1([CH3:22])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH:10]=2)[O:3]1.[ClH:23]>CC(OC)(C)C.CCOCC>[ClH:23].[CH3:7][C:6]1([CH3:8])[C:2]([CH3:1])([CH3:22])[O:3][B:4]([C:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=2)[O:5]1参加物
5
反応物 2
生成物 1
試薬・触媒・溶媒 2
実験手順
tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (2 g, 6.47 mmol) was suspended in MTBE (8.1 mL) and 2M HCl in Et2O (24 mL). The reaction was stirred rt overnight, the white precipitate formed collected by filtration and washed with Et2O to give the title compound (1.434 g, 90%).
後処理
- customthe white precipitate formed
- filtrationcollected by filtration
- washwashed with Et2O
出典と根拠
- ORDレコード
- ord-76777c072ba54fb8bb2b8c2d6126188d
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09321776B2
反応ノート
読み込み中…