Hydrochloric Acid → 6-Methoxy-7-(2-methylthioethoxy)-3,4-dihydroquinazolin-4-one hydrochloride

HRID 634696ノート

反応式

HRID 634696 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][S:16][CH3:17])[N:9]=[CH:8][N:7]=[C:6]2[O:18]C1C=CC=CC=1.[ClH:25]>C(Cl)Cl>[ClH:25].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][S:16][CH3:17])[N:9]=[CH:8][NH:7][C:6]2=[O:18]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 212602746-Methoxy-7-(2-methylthioethoxy)4-phenoxyquinazoline

生成物 1

HCID 1355493866-Methoxy-7-(2-methylthioethoxy)-3,4-dihydroquinazolin-4-one hydrochloride収率 83%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
100 °C

実験手順

A mixture of 6-methoxy-7-(2-methylthioethoxy)-4-phenoxyquinazoline (1.5 g, 4.4 mmol) and 2M hydrochloric acid (25 ml) was heated at 100° C. for 2 hours. The mixture was allowed to cool, and methylene chloride was added with stirring to give a white precipitate. The precipitate was collected by filtration, washed with water and methylene chloride and dried to give 6-methoxy-7-(2-methylthioethoxy)-3,4-dihydroquinazolin-4-one hydrochloride (1.1 g, 83%).

後処理

  1. temperatureto cool
  2. customto give a white precipitate
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water and methylene chloride
  5. customdried

出典と根拠

ORDレコード
ord-98486ddbb3a9462fb5adfc6a339eb780
出典データセット
uspto-grants-2001_02
特許番号
US06184225B2

反応ノート

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