Hydrochloric Acid → 3-(Morpholin-4-yl)propanoic acid

HRID 634733

反応式

HRID 634733 の反応式
[OH-].[K+].[O:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]([O:13]C)=[O:12])[CH2:5][CH2:4]1.Cl>C(O)C>[O:3]1[CH2:4][CH2:5][N:6]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:7][CH2:8]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 1013734-Morpholinepropanoic acid, methyl ester

生成物 1

HCID 4108133-(Morpholin-4-yl)propanoic acid収率 109.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

Potassium hydroxide (485 mg, 8.6mmol) was added to a solution of methyl 3-morpholinopropionate (1 g, 5.7 mmol) in ethanol (20 ml) and the mixture stirred for 2 hours at 80° C. The solution was allowed to cool and adjusted to pH1 with 6M hydrochloric acid. Insoluble material was removed by filtration and the volatiles removed from the filtrate by evaporation. The resulting oil was triturated with ether, the solid product collected by filtration, washed with methylene chloride and dried under vacuum to give 3-morpholinopropionic acid (993 mg, 89%) as a white solid.

後処理

  1. temperatureto cool
  2. customInsoluble material was removed by filtration
  3. customthe volatiles removed from the filtrate by evaporation
  4. customThe resulting oil was triturated with ether
  5. filtrationthe solid product collected by filtration
  6. washwashed with methylene chloride
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-86cdfda27d254be487ffcb57eed83c91
出典データセット
uspto-grants-2001_02
特許番号
US06184225B2

関連ノート

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