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2-Methyl-4-methoxyaniline → N-(4-Methoxy-2-methylphenyl)-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methyl-4-methoxyaniline | HCID 7610 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | N-(4-Methoxy-2-methylphenyl)-acetamide | HCID 95082 | 88% |
反応手順
Acetic anhydride (50 ml) was added dropwise to a solution of 4-methoxy-2-methylaniline (49.7 g, 360mmol) in DMA (200 ml) at 5° C. and the mixture stirred for 4.5 hours at ambient temperature. The solvent was removed by evaporation and the resulting solid washed with water and dried under vacuum to give N-(4-methoxy-2-methylphenyl)acetamide (57.3 g, 88%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06184225B2 |
| 出典データセット | uspto-grants-2001_02 |
| ORD ID | ord-176f1a6305aa4a55a6e8c9853f2cfc64 |
| 出典メモ | uspto-grants-2001_02 |