2-Acetamido-5-methoxy-4-nitrobenzoic acid → 2-Amino-4-nitro-5-methoxybenzoic Acid
反応式
C([NH:4][C:5]1[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[C:11]([O:17][CH3:18])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(=O)C>O.Cl>[NH2:4][C:5]1[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[C:11]([O:17][CH3:18])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]参加物
4
反応条件
- 温度
- 0 °C
実験手順
A solution of 2-acetamido-5-methoxy-4-nitrobenzoic acid (21.6 g, 85 mmol) in water (76 ml) and concentrated hydrochloric acid (30.5 ml) was heated at reflux for 3 hours. The reaction mixture was cooled to 0° C., the resulting solid was collected by filtration, washed with water and dried under vacuum to give 2-amino-5-methoxy-4-nitrobenzoic acid (I 6.6 g, 92%).
後処理
- temperatureat reflux for 3 hours
- filtrationthe resulting solid was collected by filtration
- washwashed with water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-81d073c9ba1f4d358902b3c0b4520d2f
- 出典データセット
- uspto-grants-2001_02
- 特許番号
- US06184225B2
反応ノート
読み込み中…