Formamide → 6-Methoxy-7-nitroquinazolin-4(3H)-one
反応式
[NH2:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([O:14][CH3:15])=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:16]([NH2:18])=O>O>[CH3:15][O:14][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][C:9]=1[N+:11]([O-:13])=[O:12])[N:1]=[CH:16][NH:18][C:4]2=[O:6]参加物
4
反応条件
- 温度
- 0 °C
実験手順
A solution of 2-amino-5-methoxy-4-nitrobenzoic acid (1 6.6 g, 78 mmol) in formamide (250 ml) was heated at reflux for 4.5 hours. The reaction mixture was cooled to 0° C., diluted with water and the resulting precipitate collected by filtration, washed with water and dried under vacuum to give 6-methoxy-7-nitro-3,4-dihydroquinazolin-4-one ( 11.56 g, 67%).
後処理
- temperatureat reflux for 4.5 hours
- filtrationthe resulting precipitate collected by filtration
- washwashed with water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-ed43d6a74e77410e8317dfed80d62c92
- 出典データセット
- uspto-grants-2001_02
- 特許番号
- US06184225B2
反応ノート
読み込み中…