Ammonia → 3-amino-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

HRID 634850ノート

反応式

HRID 634850 の反応式
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([NH:8][C:9](=[O:14])[C:10]2([CH3:13])[O:12][CH2:11]2)=[CH:6][C:5]=1[C:17]([F:20])([F:19])[F:18])([O-:3])=[O:2].[NH3:21]>CO>[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([NH:8][C:9](=[O:14])[C:10]([OH:12])([CH3:13])[CH2:11][NH2:21])=[CH:6][C:5]=1[C:17]([F:20])([F:19])[F:18])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 222AmmoniaHCID 140648402-Methyl-n-[4-nitro-3-(trifluoromethyl)phenyl]oxirane-2-carboxamide

生成物 1

HCID 100180753-amino-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide収率 58%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
-70 °C

実験手順

A pressure reactor was charged with 4-nitro-3-trifluoromethyl-N-[2,3-epoxy-2-methyl propionyl]aniline, BP-33, (10.0 g, 34.46 mmol) and methanol (100 mL). After cooling to −70° C., ammonia in excess was condensed into the reactor which was sealed and stirred 14 hours. Following evaporation, the crude solid was washed with cold CH2Cl2 (5 mL). Filtration and drying gave 6.1 g BP-34 (58% yield).

後処理

  1. customcondensed into the reactor which
  2. customwas sealed
  3. customevaporation
  4. washthe crude solid was washed with cold CH2Cl2 (5 mL)
  5. filtrationFiltration
  6. customdrying
  7. customgave 6.1 g BP-34 (58% yield)

出典と根拠

ORDレコード
ord-5d8578b7dde149db8ef2d8311db65221
出典データセット
uspto-grants-2001_02
特許番号
US06184249B2

反応ノート

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