Isopropanol → HCID 178470768、化合物
反応式
[C:1](=[S:4])([S-:3])[NH2:2].[NH4+].C(O)(C)C.Cl[CH2:11][C:12](=O)[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]>O>[CH2:17]([O:16][C:14]([CH2:13][C:12]1[N:2]=[C:1]([SH:3])[S:4][CH:11]=1)=[O:15])[CH3:18]参加物
5
実験手順
To 180.0 g (1.63 mols) of ammonium dithiocarbamate was added 1.5 liters of isopropyl alcohol, the mixture was stirred and then 268.9 g (1.63 mols) of ethyl 4-chloro-3-oxobutanoate was added dropwise to the mixture. After stirring the resultant mixture for 3 hours under refluxing, 300 ml of water was added to the reaction mixture, the mixture was cooled to room temperature and crystals formed were collected by filtration under a reduced pressure to obtain crude crystals. The crude crystals were recrystallized from ethyl acetate to obtain 188 g (yield 57%) of 4-ethoxycarbonylmethyl-2-mercaptothiazole.
後処理
- temperatureunder refluxing
- customcrystals formed
- filtrationwere collected by filtration under a reduced pressure
- customto obtain crude crystals
- customThe crude crystals were recrystallized from ethyl acetate
出典と根拠
- ORDレコード
- ord-22ec9ce4adfa4f94b6cc27b7408e9e2b
- 出典データセット
- uspto-grants-2001_02
- 特許番号
- US06184386B2
反応ノート
読み込み中…