Acetic Anhydride → N-(4-Iodophenyl)acetamide

HRID 635230

反応式

HRID 635230 の反応式
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>C(Cl)Cl>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:9](=[O:11])[CH3:10])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 108934-Iodoaniline

生成物 1

HCID 12147N-(4-Iodophenyl)acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-Iodo-aniline (15 g, 69 mmol) in dry CH2Cl2 (100 ml) was added acetic anhydride(14.09 g, 138 mmol) at room temperature, the reaction mixture was then stirred for 2 hr. The gray color precipitate formed during the reaction was filtered, washed with ether and collected, the mother solution was concentrated to dryness and AcOEt was added, the resulting precipitate was filtered, washed with ether and combined with the previous solid as the desired product (15.95 g, 88.7%).

後処理

  1. customThe gray color precipitate
  2. customformed during the reaction
  3. filtrationwas filtered
  4. washwashed with ether
  5. customcollected
  6. concentrationthe mother solution was concentrated to dryness and AcOEt
  7. additionwas added
  8. filtrationthe resulting precipitate was filtered
  9. washwashed with ether

出典と根拠

ORDレコード
ord-00f4b8765ab64c0a831636bb8ed27486
出典データセット
uspto-grants-2001_02
特許番号
US06187792B1

関連ノート

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