Trimethyl phosphite → 4-(Dimethoxy-phosphorylmethyl)-benzoic acid methyl ester

HRID 635231ノート

反応式

HRID 635231 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11]Br)=[CH:7][CH:6]=1)=[O:4].[P:13]([O:18]C)([O:16][CH3:17])[O:14][CH3:15]>>[CH3:1][O:2][C:3](=[O:4])[C:5]1[CH:10]=[CH:9][C:8]([CH2:11][P:13]([O:16][CH3:17])([O:14][CH3:15])=[O:18])=[CH:7][CH:6]=1

参加物

3

反応物 2

HCID 8472Trimethyl phosphiteHCID 256687Methyl 4-(bromomethyl)benzoate2 回

生成物 1

HCID 108011704-(Dimethoxy-phosphorylmethyl)-benzoic acid methyl ester

実験手順

Methyl 4-(bromomethyl) benzoate (compound 47) (11.2 g, 49 mmol) was dissolved in 25 mL trimethyl phosphite and refluxed under N2 for 5 hrs. Excess trimethyl phosphite was removed by co-distillation with toluene to give crude 4-(Dimethoxy-phosphorylmethyl)-benzoic acid methyl ester (compound 48).

後処理

  1. temperaturerefluxed under N2 for 5 hrs
  2. customExcess trimethyl phosphite was removed by co-distillation with toluene

出典と根拠

ORDレコード
ord-3d483c3b74624bc3b5db8015348cd15f
出典データセット
uspto-grants-2001_02
特許番号
US06187792B1

反応ノート

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