Cycloheptanone Oxime → 3-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole

HRID 635305

反応式

HRID 635305 の反応式
[C:1]1(=[N:8][OH:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][C:26](OCC)=O)[CH2:19][CH2:18]2)=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:12]=[CH:13][C:14]([N:17]2[CH2:18][CH2:19][N:20]([CH2:23][CH2:24][CH2:25][C:26]3[O:9][N:8]=[C:1]4[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]=34)[CH2:21][CH2:22]2)=[CH:15][CH:16]=1

参加物

3

反応物 2

HCID 137457Cycloheptanone OximeHCID 14879737Ethyl 4-(4-(4-fluorophenyl)piperazin-1-yl)-n-butyrate

生成物 1

HCID 599393903-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole

実験手順

By the same reaction and treatment as in Example 48 using cycloheptanone oxime and ethyl 4-(4-(4-fluorophenyl)piperazin-1-yl)-n-butyrate, 3-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole is obtained.

出典と根拠

ORDレコード
ord-8eaf9fdf7459475f955d69283930761d
出典データセット
uspto-grants-2001_02
特許番号
US06187774B1

関連ノート

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