2-Bromo-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethan-1-one → HCID 21258525、化合物
反応式
[Br:1][CH2:2][C:3]([C:5]1([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[CH2:8][CH2:7][CH2:6]1)=[O:4].[N:17]1[CH2:22][CH2:21][CH2:20][NH:19][C:18]=1[SH:23]>CC(C)=O>[BrH:1].[Cl:16][C:11]1[CH:10]=[C:9]([C:5]2([C:3](=[O:4])[CH2:2][S:23][C:18]3[NH:19][CH2:20][CH2:21][CH2:22][N:17]=3)[CH2:8][CH2:7][CH2:6]2)[CH:14]=[CH:13][C:12]=1[Cl:15]参加物
4
実験手順
A solution of 2-bromo-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethanone (3.2 g) in acetone (25 ml) was added to a solution of 3,4,5,6-tetrahydropyrimidine-2-thiol (1.2 g) in acetone (150 mL), then the mixture was heated under reflux for 0.5 hour, and allowed to cool to ambient temperature. The resulting solid was collected by filtration and dried in vacuo at ambient temperature to give 1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-(3,4,5,6-tetrahydropyrimidin-2-ylthio)ethanone hydrobromide as a white solid (3.9 g), m.p. 203-204° C.