Bromine → 1-Bromo-3-(3,4-dichlorophenyl)-3-methylbutan-2-one

HRID 635366ノート

反応式

HRID 635366 の反応式
[Br:1]Br.[Cl:3][C:4]1[CH:5]=[C:6]([C:11]([CH3:16])([CH3:15])[C:12](=[O:14])[CH3:13])[CH:7]=[CH:8][C:9]=1[Cl:10]>CCOCC>[Br:1][CH2:13][C:12](=[O:14])[C:11]([C:6]1[CH:7]=[CH:8][C:9]([Cl:10])=[C:4]([Cl:3])[CH:5]=1)([CH3:16])[CH3:15]

参加物

4

反応物 2

HCID 24408Bromine2 回HCID 212584633-(3,4-Dichlorophenyl)-3-methylbutan-2-one

生成物 1

HCID 212583981-Bromo-3-(3,4-dichlorophenyl)-3-methylbutan-2-one

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of bromine (1.84 ml) in ether (25 ml) was added dropwise over 1 hour at ambient temperature to a stirred solution of 3-(3,4-dichlorophenyl)-3-methylbutan-2-one (8.24 g) in ether (250 ml). After the addition was complete and the bromine colour had dissipated, the mixture was stirred at ambient temperature for a further 30 minutes then it was washed with water (100 ml), saturated aqueous sodium hydrogen carbonate solution (2×100 ml) and water (100 ml), dried (MgSO4), and the solvent removed in vacuo to give 1-bromo-3-(3,4-dichlorophenyl)-3 methylbutan-2-one as an oil (9.57 g) which was used without purification.

後処理

  1. additionAfter the addition
  2. washit was washed with water (100 ml), saturated aqueous sodium hydrogen carbonate solution (2×100 ml) and water (100 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-f4432f27840448dfbfc35022ab7c5e91
出典データセット
uspto-grants-2001_02
特許番号
US06187802B1

反応ノート

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