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Pyrazinamide → 2-Pyrazinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrazinamide | HCID 1046 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | 2-Pyrazinecarboxylic acid | HCID 1047 | 111.6% |
反応手順
Thionyl chloride (10 mL) is added to a 25 mL round bottom flask in an ice bath. To the flask is added 800 mg (6.5 mmole) of 2-Pyrazinecarboxylic acid 74, and the mixture stirred for 5 minutes. Dimethyl formamide (1.02 g mg, 14 mmole) is added in a single portion, and the orange/red solution stirred for 90 minutes. The solvents are removed under reduced pressure to give 80 (0.900 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06187928B1 |
| 出典データセット | uspto-grants-2001_02 |
| ORD ID | ord-ebc97d578ea74eb19d74918e05610308 |
| 出典メモ | uspto-grants-2001_02 |