化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3-Chloro-4-fluorobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 3'-Chloro-4'-fluoroacetophenone | HCID 520422 | — |
| 反応物 | Sodium Bisulfite | HCID 23665763 | — |
| 反応物 | Sodium hypobromite | HCID 23673712 | — |
| 生成物 | 3-Chloro-4-fluorobenzoic acid | HCID 520989 | 74% |
反応手順
The 3-chloro-4-fluoroacetophenone is then reacted with an aqueous solution of sodium hypobromite, the aqeuous phase is treated with sodium hydrogensulfite and acidified with hydrochloric acid, and the precipitated product is recrystallized from benzene. 3-Chloro-4-fluorobenzoic acid obtained in a yield of 74%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06187952B1 |
| 出典データセット | uspto-grants-2001_02 |
| ORD ID | ord-d546c0be93c5496da77831fb43df7de5 |
| 出典メモ | uspto-grants-2001_02 |