Acetate → HCID 178418277、化合物

HRID 635552

反応式

HRID 635552 の反応式
[C:1]([O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][NH2:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(=O)C.[N:20]#[C:21][NH2:22].C([O-])(=O)C>>[C:1]([O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][NH:15][C:21]([NH2:22])=[NH:20])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 4

HCID 175AcetateHCID 176Acetic AcidHCID 9864CyanamideHCID 212595702-(2-Aminoethoxy)ethyl benzoate

生成物 1

HCID 178418277HCID 178418277、化合物収率 62.1%

反応条件

温度
90 °C

実験手順

2.14 g (10.2 mmol) of 2-(2-aminoethoxy)ethyl benzoate and 0.624 g (10.4 mmol) of acetic acid were placed in a 50 ml two neck flask. While heating the flask in a 90° C. oil bath, 0.680 g (16.2 mmol) of cyanamide was added. After 6 hours of the reaction, the product was purified by a silica gel column chromatography (eluent, chloroform/ethanol=1/2 containing 0.5% acetic acid) to obtain 1.97 g of the title compound (wax-like, 6.33 mmol, 62.0% in yield) in the form of acetate. Results of the analysis of this compound are as follows.

後処理

  1. customAfter 6 hours of the reaction
  2. customthe product was purified by a silica gel column chromatography (eluent, chloroform/ethanol=1/2 containing 0.5% acetic acid)

出典と根拠

ORDレコード
ord-69efec1012bb4f988207832baf3b7aac
出典データセット
uspto-grants-2001_02
特許番号
US06187955B1

関連ノート

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