Triacetoxyperiodinane → 3(S)-(tert-butoxyformamido)-2-oxo-N-(1(S)-phenylpropyl)heptanamide

HRID 635639

反応式

HRID 635639 の反応式
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C1=CC=CC=2)=O.[C:23]([O:27][C:28]([NH:30][C@@H:31]([CH2:46][CH2:47][CH2:48][CH3:49])[C@H:32]([OH:45])[C:33]([NH:35][C@H:36]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[CH2:37][CH3:38])=[O:34])=[O:29])([CH3:26])([CH3:25])[CH3:24]>ClCCl.C(OCC)(=O)C>[C:23]([O:27][C:28]([NH:30][C@@H:31]([CH2:46][CH2:47][CH2:48][CH3:49])[C:32](=[O:45])[C:33]([NH:35][C@H:36]([C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1)[CH2:37][CH3:38])=[O:34])=[O:29])([CH3:26])([CH3:25])[CH3:24]

参加物

5

反応物 2

HCID 159087Triacetoxyperiodinane2 回HCID 206399793(S)-(tert-butoxyformamido)-2(S)-hydroxy-N-(1(S)-phenylpropyl)heptanamide

生成物 1

HCID 206399773(S)-(tert-butoxyformamido)-2-oxo-N-(1(S)-phenylpropyl)heptanamide収率 70.6%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

0.383 g of 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one was added to a solution of 0.285 g of 3(S)-(tert-butoxyformamido)-2(S)-hydroxy-N-(1(S)-phenylpropyl)heptanamide in 20 ml of dichloromethane. The mixture was stirred at room temperature for 30 minutes and then a further 30 mg of 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one were added. The mixture was stirred at room temperature for 30 minutes and then diluted with ethyl acetate. The solution was extracted with a solution of 10 g of sodium thiosulphate in 40 ml of saturated sodium bicarbonate solution. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with water, dried over magnesium sulphate and evaporated. The residue was purified by chromatography on silica gel using 20% ethyl acetate in hexane for the elution to give 200 mg of 3(S)-(tert-butoxyformamido)-2-oxo-N-(1(S)-phenylpropyl)heptanamide, MS: m/e 377.1 [M+H]+.

後処理

  1. stirringThe mixture was stirred at room temperature for 30 minutes
  2. extractionThe solution was extracted with a solution of 10 g of sodium thiosulphate in 40 ml of saturated sodium bicarbonate solution
  3. extractionThe aqueous layer was extracted with ethyl acetate
  4. washthe combined organic layers were washed with water
  5. dry with materialdried over magnesium sulphate
  6. customevaporated
  7. customThe residue was purified by chromatography on silica gel using 20% ethyl acetate in hexane for the elution

出典と根拠

ORDレコード
ord-1f96bf04c2014bce81f9c620da14c3a0
出典データセット
uspto-grants-2001_02
特許番号
US06187905B1

関連ノート

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