Toluene → (E)-tert-Butyl hept-2-enoate
反応式
[C:1]([OH:9])(=[O:8])/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH3:7].[C:10]1([CH3:16])[CH:15]=CC=C[CH:11]=1>>[C:1]([O:9][C:10]([CH3:16])([CH3:15])[CH3:11])(=[O:8])/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH3:7]参加物
3
実験手順
74.79 ml (312 mmol) of 1,2-(di-tert-butyl)trimethylamine were added to a stirred mixture of 5 g (39 mmol) of (E)-2-heptenoic acid in 100 ml of toluene at 80° C. The mixture was stirred under reflux for 30 minutes and then cooled to room temperature. The mixture was washed in sequence with water and saturated sodium bicarbonate solution, then dried over anhydrous magnesium sulphate and filtered. The solvent was removed by evaporation. There were obtained 7.5 g of tert-butyl (E)-2-heptenoate as a yellow oil; MS: m/e 185.0 [M+H].
後処理
- temperatureunder reflux for 30 minutes
- washThe mixture was washed in sequence with water and saturated sodium bicarbonate solution
- dry with materialdried over anhydrous magnesium sulphate
- filtrationfiltered
- customThe solvent was removed by evaporation
出典と根拠
- ORDレコード
- ord-9780b1716e3747bd9ff011df2d496175
- 出典データセット
- uspto-grants-2001_02
- 特許番号
- US06187905B1
反応ノート
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