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Benzaldehyde → 3-[3-(2,3-Dimethylimidazo[2,1-b]thiazol-5-yl)-3-oxo-1-propenyl]phenyl-4-methylbenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | o-Toluenesulfonyl chloride | HCID 8623 | — |
| 反応物 | Benzaldehyde, 3-amino- | HCID 74366 | — |
| 反応物 | m-Toluenesulphonamide | HCID 74697 | — |
| 反応物 | 2,3-Dimethylimidazo[2,1-b]thiazol-5-yl ethanone | HCID 21256445 | — |
| 生成物 | 3-[3-(2,3-Dimethylimidazo[2,1-b]thiazol-5-yl)-3-oxo-1-propenyl]phenyl-4-methylbenzenesulfonamide | HCID 86756428 | — |
反応手順
1-(2,3-Dimethylimidazo[2,1-b]-thiazol-5-yl ethanone (Formula N′-1), 0.97 g, was condensed with the 3-toluensulfonamide of benzaldehyde, m.p. 126-127°, prepared from toluene sulfonyl chloride and 3-aminobenzaldehyde, according to non-critical modifications of PREPARATION 15 to provide pure (E)-N-[3-[3-(2,3-Dimethylimidazo[2,1-b]thiazol-5-yl)-3-oxo-1-propenyl]phenyl-4-methylbenzenesulfonamide, m.p. 236-237°, Formula N′-2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06191124B1 |
| 出典データセット | uspto-grants-2001_02 |
| ORD ID | ord-ed899c7d24cd4a589abc1bab3ad8f41e |
| 出典メモ | uspto-grants-2001_02 |