1H-Indazole → 5-bromo-6-chloro-2-(1H-indazol-1-yl)pyrimidine-4-amine

HRID 63603

反応式

HRID 63603 の反応式
[Br:1][C:2]1[C:3]([NH2:12])=[N:4][C:5](S(C)=O)=[N:6][C:7]=1[Cl:8].[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[N:14]1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[Br:1][C:2]1[C:3]([NH2:12])=[N:4][C:5]([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[N:14]2)=[N:6][C:7]=1[Cl:8]

参加物

5

反応物 3

HCID 92211H-IndazoleHCID 10796Cesium carbonateHCID 866770165-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine2 回

生成物 1

HCID 903037965-bromo-6-chloro-2-(1H-indazol-1-yl)pyrimidine-4-amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a vigorously stirring suspension of 2 g (7.4 mmol) of 5-bromo-6-chloro-2-(methylsulfinyl)pyrimidine-4-amine (intermediate 3) in 40 ml of DMF, 0.87 g (7.4 mmol) indazole and 1.4 g (4.4 mmol) of cesium carbonate were added. The reaction mixture was stirred at room temperature for 20 minutes. The solution was poured onto 200 ml of ice-water. The resulting precipitate was filtered, washed with cold water and dried. The desired product is obtained as a white solid 1.31 g (54.6%)

後処理

  1. additionwere added
  2. stirringThe reaction mixture was stirred at room temperature for 20 minutes
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with cold water
  5. customdried

出典と根拠

ORDレコード
ord-23f4826a7a51422ba90abdbedf459d76
出典データセット
uspto-grants-2016_09
特許番号
US09447095B2

関連ノート

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