関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4,6-Dichloro-2-(methylthio)pyrimidine | HCID 80531 | — |
| 反応物 | Propargylamine | HCID 239041 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 6-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amine | HCID 90303691 | 99.4% |
反応手順
A mixture of 1.00 g (5.13 mmol) of 4,6-dichloro-2-(methylthio)pyrimidine and 0.7 ml (10.3 mmol) of propargylamine in 10 ml of acetonitrile was stirred for 12 hours at 60° C. The reaction solution was poured onto cold water. Then, the formed precipitate was filtered, washed several times with cold water and dried. 1.09 g of a light yellow solid were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09447095B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-01225f880448429ca0699b60ca00ba14 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
