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Diethyl Ether → p-Cyclohexylbenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 18-Crown-6 | HCID 28557 | — |
| 反応物 | (4-Cyclohexylphenyl)methanol | HCID 22492024 | — |
| 反応物 | HCID 178418287 | HCID 178418287 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | p-Cyclohexylbenzaldehyde | HCID 119689 | — |
反応手順
18-Crown-6 (Aldrich; 4 molar eq.) and pyridinium chlorochromate (Aldrich; 4 molar eq.) were added together in chloroform and stirred for 20 minutes. 4-Cyclohexylbenzylalcohol (from Example D22 below; 1 molar eq.) was added and stirring continued for 3 hours. Ether was added and the mixture filtered through a plug of silica eluting with ether. The solvent was removed via rotary evaporation. The residue was dissolved in ether and washed with water. The organic layer was dried over Na2SO4, filtered, and concentrated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06191166B1 |
| 出典データセット | uspto-grants-2001_02 |
| ORD ID | ord-ad55b80dab7b4b94806b68929f69acf1 |
| 出典メモ | uspto-grants-2001_02 |