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HRID 636164作成日：2026年10月27日

Hydrochloric Acid → H-Ala(3-pyridyl)-OMe.2HCl

https://huagongshe.com/reaction/636164

反応式

関与物質

役割名称HCID仕込み量
反応物Hydrochloric AcidHCID 313—
反応物Diethyl acetamido[(pyridin-3-yl)methyl]propanedioateHCID 13817914—
生成物H-Ala(3-pyridyl)-OMe.2HClHCID 46862166100%

反応手順

Diethyl 2-(3-pyridylmethyl)-2-acetamidomalonate was dissolved in 6N HCl (30 mL) and heated to reflux for 19 hours whereupon it was cooled to room temperature and the HCl solution was removed by evaporation in vacuo. The intermediate amino acid dihydrochloride salt was taken up into MeOH (30 mL) saturated with HCl gas and stirred for 3.5 hours. The MeOH/HCl was removed by evaporation in vacuo to give 3-(3-pyridyl)alanine methyl ester dihydrochloride (2.235 g, 100%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06191166B1
出典データセットuspto-grants-2001_02
ORD IDord-3b4eb682c8a3415d896cf748e834412d
出典メモuspto-grants-2001_02