Dimethylformamide → 3-Benzenesulphonyl-7-(4-benzyl-piperazin-1-yl)-5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidine

反応式

[CH2:1]([N:8]1[CH2:13][CH2:12]C[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:14]1([S:20]([C:23]2[C:24]([S:34][CH3:35])=[N:25][N:26]3[C:31](Cl)=[CH:30][C:29]([CH3:33])=[N:28][C:27]=23)(=[O:22])=[O:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C[N:37](C=O)C>>[C:14]1([S:20]([C:23]2[C:24]([S:34][CH3:35])=[N:25][N:26]3[C:31]([N:37]4[CH2:10][CH2:9][N:8]([CH2:1][C:2]5[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=5)[CH2:13][CH2:12]4)=[CH:30][C:29]([CH3:33])=[N:28][C:27]=23)(=[O:22])=[O:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

反応物 3

HCID 6228Dimethylformamide

HCID 761901-Benzylpiperidine

HCID 109810973-Benzenesulphonyl-7-chloro-5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidine

生成物 1

HCID 212550553-Benzenesulphonyl-7-(4-benzyl-piperazin-1-yl)-5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidine収率 73%

実験手順

0.35 g (2 mmol) of N-benzyl-piperidine was added to a solution of 0.35 g (1 mmol) of 3-benzenesulphonyl-7-chloro-5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidine in 5 ml of DMF and stirred at 60° for 2 hrs. The reaction solution was cooled to RT and evaporated in a high vacuum. The residue was partitioned between 2N NaOH and CH2Cl2. The aqueous phase was extracted three times with CH2Cl2, and the combined organic phases were dried (MgSO4), filtered and evaporated. Subsequent chromatography (SiO2, CH2Cl2/MeOH 19:1) and crystallization from EtOH yielded 0.36 g (73%) of 3-benzenesulphonyl-7-(4-benzyl-piperazin-1-yl)-5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidine as colorless crystals m.p. 156-158°.