Formic Acid → N-(1,3-dihydro-2-benzofuran-5-yl)formamide
反応式
[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[CH2:3][O:2]1.[CH:11](O)=[O:12]>>[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][CH:11]=[O:12])=[CH:9][C:4]=2[CH2:3][O:2]1参加物
3
実験手順
1,3-Dihydro-2-benzofuran-5-amine (300 mg, 2.2 mmol) was added to HCOOH (10 mL), and the reaction was stirred at reflux overnight. The reaction was concentrated, basified to pH=8 with sat Na2CO3, and extracted with EtOAc. Organics were washed with brine, dried (Na2SO4), and concentrated to give 250 mg (69%) of N-(1,3-dihydro-2-benzofuran-5-yl)formamide as a yellow oil.
後処理
- temperatureat reflux overnight
- concentrationThe reaction was concentrated
- extractionextracted with EtOAc
- washOrganics were washed with brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-7535fa64e1b44f0aa936eef954ce8d4b
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447046B2
反応ノート
読み込み中…