2,3-Dichlorobenzaldehyde → Propan-2-yl 4-(2,3-dichlorophenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

HRID 636536ノート

反応式

HRID 636536 の反応式
[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH:11]1([CH:18]=[CH:17][CH:16]=[C:14]([OH:15])[CH2:13]1)O.[NH2:19]/[C:20](/[CH3:28])=[CH:21]\[C:22]([O:24][CH:25]([CH3:27])[CH3:26])=[O:23]>C(O)(C)C>[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]1[C:13]2[C:14](=[O:15])[CH2:16][CH2:17][CH2:18][C:11]=2[NH:19][C:20]([CH3:28])=[C:21]1[C:22]([O:24][CH:25]([CH3:27])[CH3:26])=[O:23]

参加物

5

反応物 3

HCID 357452,3-DichlorobenzaldehydeHCID 111372742-Butenoic acid, 3-amino-, 1-methylethyl esterHCID 19922823Cyclohexa-3,5-diene-1,3-diol

生成物 1

HCID 2847040Propan-2-yl 4-(2,3-dichlorophenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

3.50 g (20 mmol) of 2,3-dichlorobenzaldehyde, 2.24 g (20 mmol) of dihydroresorcinol and 2.86 g (20 mmol) of isopropyl 3-aminocrotonate are dissolved in 100 ml of isopropanol and stirred under reflux for 5 h. The product precipitates. The mixture is treated with 50 ml of water and cooled to RT. The product is filtered off with suction and washed successively with isopropanol, ethanol and ether. 5.8 g (74% of theory) of the title compound are obtained.

後処理

  1. temperatureunder reflux for 5 h
  2. customThe product precipitates
  3. additionThe mixture is treated with 50 ml of water
  4. filtrationThe product is filtered off with suction
  5. washwashed successively with isopropanol, ethanol and ether

出典と根拠

ORDレコード
ord-a0fa06fea45c46718f7d1b60eac63f03
出典データセット
uspto-grants-2001_02
特許番号
US06194428B1

反応ノート

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