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Sulfuric Acid → 3-Nitropyridin-2-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 2-Chloropyridine | HCID 7977 | — |
| 反応物 | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 溶媒 | Diglyme | HCID 8150 | — |
| 生成物 | 3-Nitropyridin-2-ylamine | HCID 77887 | — |
反応手順
A general synthesis route begins with 2-chloropyridine which is nitrated in the presence of sulfuric acid to make 2-chloro-3-nitropyridine. This material is reacted with ammonium acetate in the presence of diglyme at about 160° C. to form 2-amino-3-nitropyridine which is reduced to form 2,3-diaminopyridine. The 2,3-diaminopyridine is reacted with 2-thiophenecarboxylic acid in the presence of polyphosphoric acid at about 125° C. to prepare 2-(2-thienyl)imidazolo [4,5]pyridine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06194430B1 |
| 出典データセット | uspto-grants-2001_02 |
| ORD ID | ord-a5d0e9606d7b42a998db3f5e949b214e |
| 出典メモ | uspto-grants-2001_02 |