反応式
[S:1]1[CH:5]=[C:4]([C:6]([OH:8])=[O:7])[N:3]=[CH:2]1.[F:9][C:10]1[N:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](O)=[O:13]>>[F:9][C:10]1[N:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([N:3]1[C:4]([C:6]([OH:8])=[O:7])=[CH:5][S:1][CH2:2]1)=[O:13]参加物
3
実験手順
N-(2-Fluoronicotinoyl)thiazole-4-carboxylic acid is prepared as described in Example 5 from 11.03 g of thiazole-4-carboxylic acid and 11.7 g of 2-fluoronicotinic acid. 8.7 g of N-(2-fluoronicotinoyl)thiazole-4-carboxylic acid are thus obtained in the form of a cream solid. (Rf=0.33; thin layer chromatography on silica gel; eluent: ethyl acetate/acetic acid, 90/10 by volume).
後処理
- customN-(2-Fluoronicotinoyl)thiazole-4-carboxylic acid is prepared
出典と根拠
- ORDレコード
- ord-f02f7051a7cb493fb766c2df78543567
- 出典データセット
- uspto-grants-2001_02
- 特許番号
- US06194426B1
関連ノート
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