Ammonium Chloride → 1,3-Thiazole-2-carboximidamide hydrochloride

HRID 63670ノート

反応式

HRID 63670 の反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]#[N:7].C[O-].[Na+].[Cl-:11].[NH4+:12]>CO>[ClH:11].[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]([NH2:12])=[NH:7]

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 10942334Sodium MethoxideHCID 151114801,3-Thiazole-2-carbonitrile

生成物 1

HCID 186795841,3-Thiazole-2-carboximidamide hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a stirred solution of thiazole-2-carbonitrile (1.5 g, 14 mmol) in 5 mL of dry MeOH was added dropwise a solution of sodium methoxide (0.74 g, 14 mmol) in 10 mL of dry methanol. The reaction mixture was stirred at room temperature until the disappearance of starting material which was checked by LC/MS. After that, ammonium chloride (1.5 g, 28 mmol) was added in one portion and the reaction mixture was stirred overnight. The undissolved material was removed by filtration and the filtrate was concentrated to afford thiazole-2-carboxamidine hydrochloride (Compound A1) as a grey solid which was used directly in the next step without further purification. MS: calc'd 128 (MH+), measured 128 (MH+).

後処理

  1. stirringthe reaction mixture was stirred overnight
  2. customThe undissolved material was removed by filtration
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-24aef6e0a5a042c68a0a6ee416267029
出典データセット
uspto-grants-2016_09
特許番号
US09447086B2

反応ノート

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