2-Methoxybenzoyl chloride → 1-(2-methoxyphenyl)-1-oxo-2-aza-4-(R)-ethyl-4-phenylbutane

反応式

[C:1]1([C@@H:7]([CH2:10][CH3:11])[CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12][O:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16](Cl)=[O:17]>>[CH3:12][O:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16](=[O:17])[CH2:11][CH2:10][C@@H:7]([CH2:8][NH2:9])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

反応物 2

HCID 889692-Methoxybenzoyl chloride

HCID 6993012(2R)-2-phenylbutan-1-amine

生成物 1

HCID 693356791-(2-methoxyphenyl)-1-oxo-2-aza-4-(R)-ethyl-4-phenylbutane

実験手順

The title compound was prepared from 0.2 gm of (R)-(−)-2-phenylbutyl amine and 2-mL of 4 methoxybenzoyl chloride according to procedures described in Example 2.

出典と根拠

ORDレコード: ord-8b06200c802f4a238cfcdbbb2e19237a
出典データセット: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06194458B1

反応ノート

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