Bromopinacolone → 4-tert-Butyl-thiazole-2-carboxamidine

反応式

[CH:1]1([C:4]2[N:5]=[C:6]([C:9]([NH2:11])=[NH:10])[S:7][CH:8]=2)[CH2:3][CH2:2]1.Br[CH2:13]C(=O)C(C)(C)C>>[C:1]([C:4]1[N:5]=[C:6]([C:9]([NH2:11])=[NH:10])[S:7][CH:8]=1)([CH3:2])([CH3:3])[CH3:13]

参加物

反応物 2

HCID 21642Bromopinacolone

HCID 900009164-Cyclopropyl-thiazole-2-carboxamidine

生成物 1

HCID 833857234-tert-Butyl-thiazole-2-carboxamidine

実験手順

4-tert-Butyl-thiazole-2-carboxamidine (Compound N) was prepared in analogy to Compound M with procedure shown in Example 10 by using 1-bromo-3,3-dimethyl-butan-2-one instead of 2-bromo-1-cyclopropyl-ethanone. MS: calc'd (MH+) 184, measured (MH+) 184.

出典と根拠

ORDレコード: ord-7fe6473a628d4548aa1af40b68f3751d
出典データセット: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09447086B2

反応ノート

読み込み中…