2-Bromo-1-cyclopropylethan-1-one → 4-(Trifluoromethyl)thiazole-2-carboximidamide
反応式
C1(C2N=C([C:9]([NH2:11])=[NH:10])SC=2)CC1.Br[C:13]1[S:14][CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[N:17]=1.BrCC(C1CC1)=O>>[F:19][C:18]([F:21])([F:20])[C:16]1[N:17]=[C:13]([C:9]([NH2:11])=[NH:10])[S:14][CH:15]=1参加物
4
実験手順
4-Trifluoromethyl-thiazole-2-carboxamidine (Compound U) was prepared in analogy to Compound M with procedure shown in Example 10 by using 2-bromo-4-trifluoromethyl-thiazole (CAS: 41731-39-9) instead of 2-bromo-4-cyclopropyl-thiazole which is made from 2-bromo-1-cyclopropyl-ethanone in Example 10. MS: calc'd (MH+) 196, measured (MH+) 196.
出典と根拠
- ORDレコード
- ord-c893a4a227fa4434867d182a34a06ca9
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447086B2
反応ノート
読み込み中…