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Methyl acetoacetate → (S)-4-[(R)-6-(2-Bromo-4-fluoro-phenyl)-5-ethoxycarbonyl-2-(5-methyl-oxazol-4-yl)-3,6-dihydro-pyrimidin-4-ylmethyl]-morpholine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | (S)-morpholine-3-carboxylic acid | HCID 1501894 | — |
| 反応物 | 2-Bromo-4-fluorobenzaldehyde | HCID 2773319 | — |
| 反応物 | 2-Thiazolecarboximidamide | HCID 10887911 | — |
| 反応物 | 4,4-Difluoroproline | HCID 15216102 | — |
| 反応物 | 5-Methyl-oxazole-4-carboxamidine | HCID 83677387 | — |
| 生成物 | (S)-4-[(R)-6-(2-Bromo-4-fluoro-phenyl)-5-ethoxycarbonyl-2-(5-methyl-oxazol-4-yl)-3,6-dihydro-pyrimidin-4-ylmethyl]-morpholine-3-carboxylic acid | HCID 73330831 | — |
反応手順
The title compound was prepared in analogy to Example 1 with Procedure A shown in Scheme 4 by using 2-bromo-4-fluorobenzaldehyde, 5-methyl-oxazole-4-carboxamidine (Compound AB), ethyl acetoacetate and (S)-morpholine-3-carboxylic acid instead of 2-chloro-4-fluorobenzaldehyde, thiazole-2-carboxamidine, methyl acetoacetate and (S)-4,4-difluoro-pyrrolidine-2-carboxylic acid. The stereochemistry of Example 69 was determined by comparing its 1H NMR data and HPLC retention time with Example 2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447086B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-ddeb826efca34604a1af67507d528343 |
| 出典メモ | uspto-grants-2016_09 |