[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:10]=[C:11]([CH:15]3[CH2:20][CH2:19][O:18][CH:17](C#N)[CH2:16]3)[CH:12]=[CH:13][CH:14]=2)=[CH:4][CH:3]=1.C[CH2:24][N:25](CC)CC.[C:30](Cl)(=[O:32])[CH3:31]>CCOC(C)=O>[C:24]([C:15]1([C:11]2[CH:10]=[C:9]([S:8][C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:30](=[O:32])[CH3:31])=[CH:7][CH:6]=3)[CH:14]=[CH:13][CH:12]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)#[N:25]4-[3-(4-amino-phenyl sulfanyl)-phenyl]-tetrahydro-pyran-carbonitrile (93.57 g) and Et3N (53.1 mL) were dissolved in EtOAc (1.23 L) and heated to 50-60° C. To this solution was added acetylchloride (27.7 ml) in EtOAc (73 mL) over 30 minutes. The suspension obtained was filtered and the filter cake was washed with EtOAc (3×150 mL). The combined EtOAc solutions were washed with water (0.5 L), half saturated aqueous Na2CO3 (2×0.5 L), water (0.5 L) and saturated aqueous NaCl (0.25 L). The organics were dried with Na2SO4 and evaporated at 40° C. The crude product was recrystallized from refluxing EtOH (0.52 L) to give after cooling, filtration and drying at 40° C./20 mbar, N-{4-[3-(4-Cyano-tetrahydro-pyran-4yl)-phenyl sulfanyl]-phenyl}acetamide (55.27 g, 52% yield).
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