Hydrochloric Acid → 7-Methoxy-1,2,3,4-Tetrahydroisoquinoline

HRID 636945

反応式

HRID 636945 の反応式
Cl.C(OC([N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:19][CH3:20])=[CH:14][CH:15]=2)[CH2:10]1)=O)(C)(C)C>C(OCC)C>[CH3:20][O:19][C:13]1[CH:12]=[C:11]2[C:16]([CH2:17][CH2:18][NH:9][CH2:10]2)=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 54125269tert-Butyl 7-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

生成物 1

HCID 4172887-Methoxy-1,2,3,4-Tetrahydroisoquinoline

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

At 5° C., 50 mL of a saturated solution of hydrogen chloride in diethyl ether were added dropwise to a mixture of 2.3 g of 7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester in 50 mL of diethyl ether and the reaction mixture stirred for 2 hours at room temperature. The precipitated product (hydrochloride) was separated by filtration, washed with diethyl ether and dried in vacuo. Yield: 1.5 g (7.5 mmol); m.p. 215-218° C.; EI-MS: 163 (M+).

後処理

  1. customThe precipitated product (hydrochloride) was separated by filtration
  2. washwashed with diethyl ether
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-0c0861c6dcea428c8ed8286cf21e489a
出典データセット
uspto-grants-2001_02
特許番号
US06194409B1

関連ノート

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