Acetic Acid → 2-Methylsulfonyl-5-(1H-tetrazol-1-yl)benzoic Acid

HRID 637113ノート

反応式

HRID 637113 の反応式
[CH3:1][S:2][C:3]1[CH:11]=[CH:10][C:9]([N:12]2[CH:16]=[N:15][N:14]=[N:13]2)=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].OO.C(O)(=[O:21])C.[OH2:23]>>[CH3:1][S:2]([C:3]1[CH:11]=[CH:10][C:9]([N:12]2[CH:16]=[N:15][N:14]=[N:13]2)=[CH:8][C:4]=1[C:5]([OH:7])=[O:6])(=[O:21])=[O:23]

参加物

5

反応物 4

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 962WaterHCID 184645182-Methylthio-5-(1H-tetrazol-1-yl)benzoic Acid

生成物 1

HCID 184648652-Methylsulfonyl-5-(1H-tetrazol-1-yl)benzoic Acid

反応条件

温度
100 °C

実験手順

Combine 2-methylthio-5-(1H-tetrazol-1-yl)benzoic acid (0.68 g, 0.29 mmol), 30% hydrogen peroxide (3 mL) and glacial acetic acid (20 mL). After 2 hours, heat to 100° C. After 2 hours, cool to ambient temperature and add water (250 mL) to give a solid. Collect the solid by filtration and dry to give the title compound: Rf=0.21 (silica gel, 10%; methanol/85% dichloromethane/5% acetic acid).

後処理

  1. waitAfter 2 hours
  2. temperaturecool to ambient temperature
  3. customto give a solid
  4. customCollect the solid
  5. filtrationby filtration
  6. customdry

出典と根拠

ORDレコード
ord-012c1523491f4b709f4ea9d3780b8f14
出典データセット
uspto-grants-2001_02
特許番号
US06194406B1

反応ノート

読み込み中…