HCID 18464661、化合物 → 1-(t-butoxycarbonyl)-4-(1-(2-(1H-triazol-1-yl)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane
反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[N:2]1.[C:6]([O:10][C:11]([N:13]1[CH2:19][CH2:18][CH2:17][N:16]([C:20]2[N:24]([CH2:25][CH2:26]OS(C)(=O)=O)[C:23]3[CH:32]=[CH:33][CH:34]=[CH:35][C:22]=3[N:21]=2)[CH2:15][CH2:14]1)=[O:12])([CH3:9])([CH3:8])[CH3:7]>>[C:6]([O:10][C:11]([N:13]1[CH2:19][CH2:18][CH2:17][N:16]([C:20]2[N:24]([CH2:25][CH2:26][N:1]3[CH:5]=[CH:4][N:3]=[N:2]3)[C:23]3[CH:32]=[CH:33][CH:34]=[CH:35][C:22]=3[N:21]=2)[CH2:15][CH2:14]1)=[O:12])([CH3:7])([CH3:8])[CH3:9]参加物
3
実験手順
Prepare by the method of Preparation 28 using triazole (0.045 g, 1.13 mmol) and 1-(t-butoxycarbonyl)-4-(1-(2-methanesulfonyloxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (0.33 g, 0.75 mmol) to give 1-(t-butoxycarbonyl)-4-(1-(2-(1H-triazol-1-yl)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane: Rf=0.32 (silica gel, 5% methanol/dichloromethane/0.5% concentrated aqueous ammonia).
出典と根拠
- ORDレコード
- ord-710f55ba18a640c1896f9be6c2893551
- 出典データセット
- uspto-grants-2001_02