化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 5-amino-o-anisate → Methyl5-isothiocyanato-2-methoxybenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 5-amino-o-anisate | HCID 89843 | — |
| 反応物 | O,O-Dipyridin-2-yl carbonothioate | HCID 719784 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl5-isothiocyanato-2-methoxybenzoate | HCID 18464541 | — |
反応手順
According to the method of Tet. Let., 26, 1661 (1985), combine methyl 2-methoxy-5-aminobenzoate (0.5 g, 2.76 mmol) and di-2-pyridyl thionocarbonate (0.64 g, 2.76 mmol) in dichloromethane (10 mL). After 30 minutes, dilute the reaction mixture with dichloromethane and extract five times with water. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give methyl 2-methoxy-5-isothiocyanatobenzoate: Rf=0.51 (silica gel, dichloromethane).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06194406B1 |
| 出典データセット | uspto-grants-2001_02 |
| ORD ID | ord-4ac3dee6d5d94c8aa6b1ae1554ac0251 |
| 出典メモ | uspto-grants-2001_02 |