Cyclopropanecarboxylic acid, 1-cyano-2-ethenyl-, ethyl ester → (5-Benzyl-3-furyl)methyl 2-vinyl-1-cyanocyclopropane-1-carboxylate

HRID 637247

反応式

HRID 637247 の反応式
[CH:1]([CH:3]1[CH2:5][C:4]1([C:11]#[N:12])[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH2:2].[CH2:13]([C:20]1[O:24][CH:23]=C(CO)[CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH:1]([CH:3]1[CH2:5][C:4]1([C:11]#[N:12])[C:6]([O:8][CH2:9][C:10]1[CH:21]=[C:20]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[O:24][CH:23]=1)=[O:7])=[CH2:2]

参加物

3

反応物 2

HCID 564450Cyclopropanecarboxylic acid, 1-cyano-2-ethenyl-, ethyl esterHCID 123643963-Furanmethanol, 5-(phenylmethyl)-

生成物 1

HCID 20256455(5-Benzyl-3-furyl)methyl 2-vinyl-1-cyanocyclopropane-1-carboxylate収率 85.9%

実験手順

In a manner similar to that described above, a transalcoholysis reaction was carried out using ethyl 2-vinyl-1-cyanocyclopropane-1-carboxylate and (5-benzyl-3-furyl)carbinol. The ratio of reactants, catalyst level, and reaction temperature employed were the same as indicated in Example II. (5-Benzyl-3-furyl)methyl 2-vinyl-1-cyanocyclopropane-1-carboxylate was obtained in 85.9% yield and purified by separation using the liquid chromatographic procedure. The structure of the purified (99.4%) product was confirmed by mass spectroscopy and nuclear magnetic resonance spectroscopy.

後処理

  1. customa transalcoholysis reaction
  2. customThe ratio of reactants, catalyst level, and reaction temperature

出典と根拠

ORDレコード
ord-514e208e17814541847675ad930cd0ec
出典データセット
uspto-grants-1985_12
特許番号
US04556409

関連ノート

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